Forschungsprojekte

Projekt 1a - Comparative analyses of DNA damage response pathways in hepatocytes and neurons differentiated from healthy and NBS-patient derived iPSCs

Projekt 1b - Hypoxia and Sirtuin 1, two factors linking DNA damage and differentiation in neural stem/ progenitor cells

Projekt 1c -Investigations on DNA repair capacities of human neural progenitor cells (NPC) depending on the degree of differentiation and cell type

Projekt 1d - Molecular mechanisms regulating the differentiation potential of neural stem and progenitor cells upon gamma irradiation

Projekt 1e - Impact of genotoxins on autophagic processes during neuronal differentiation

Projekt 2a - Effect of DNA damage caused by nephrotoxins and oxidative stress on differentiation and dedifferentiation processes in kidney cells

Projekt 3a - Die Auswirkung von Genotoxizität auf das Immunmikromillieu und daraus resultierende Zytopenie oder immuntherapeutische Dysfunktionalität bei chemotherapeutisch vorbehandelten Krebspatienten.

Projekt 3b - Sublethal Genomic Damage of Naïve B cells - Consequences for Differentiation and Function with a Focus on Development of Autoimmunity

Projekt 4 - Influence of nitrosamines and ionizing radiation on the chondrogenic differentiation potential of neonatal and adult stromal cells

Projekt 5a - Impact of genotoxins on cardiovascular differentiation of murine and human stem- and progenitor cells: Relevance of mechanisms of DNA repair and DNA damage response (DDR)

Projekt 5b - Role of metabolism and mitochondrial function for stem cell differentiation and stress responses upon genotoxic noxae

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