Publikationen

Scherer B, Bogun L, Koch A, Jäger P, Maus U, Schmitt L, Krings KS, Wesselborg S, Haas R, Schroeder T, Geyh S. Antineoplastic therapy affects the in vitro phenotype and functionality of healthy human bone marrow-derived mesenchymal stromal cells. Arch Toxicol. 2025 Jan;99(1):393-406. doi: 10.1007/s00204-024-03898-w. Epub 2024 Nov 12. PMID: 39531065; PMCID: PMC11742341

Shen H, Xie Y, Wang Y, Xie Y, Wang Y, Su Z, Zhao L, Yao S, Cao X, Liang J, Long J, Zhong R, Tang J, Wang S, Zhang L, Wang X, Stork B, Cui L, Wu W. The ER protein CANX (calnexin)-mediated autophagy protects against alzheimer disease. Autophagy. 2025 Jan 15:1-20. doi: 10.1080/15548627.2024.2447206. Epub ahead of print. PMID: 39813987

Bogun L, Koch A, Scherer B, Fenk R, Maus U, Bormann F, Köhrer K, Petzsch P, Wachtmeister T, Zukovs R, Dietrich S, Haas R, Schroeder T, Jäger P, Geyh S. Stromal alterations in patients with monoclonal gammopathy of undetermined significance, smoldering myeloma, and multiple myeloma. Blood Adv. 2024 May 28;8(10):2575-2588. doi: 10.1182/bloodadvances.2023011632. PMID: 38241490; PMCID: PMC11145751

Bogun L, Koch A, Scherer B, Germing U, Fenk R, Maus U, Bormann F, Köhrer K, Petzsch P, Wachtmeister T, Kobbe G, Dietrich S, Haas R, Schroeder T, Geyh S, Jäger P. Overlapping Stromal Alterations in Myeloid and Lymphoid Neoplasms. Cancers (Basel). 2024 May 30;16(11):2071. doi: 10.3390/cancers16112071. PMID: 38893194; PMCID: PMC11171322

Baumgärtner LAF, Ettich J, Balles H, Lapp DJ, Mossner S, Bassenge C, Ouzin M, Hanenberg H, Scheller J, Floss DM. Unpaired cysteine insertions favor transmembrane dimerization and induce ligand-independent constitutive cytokine receptor signaling. Biol Chem. 2024 May 3;405(7-8):531-544. doi: 10.1515/hsz-2023-0344. PMID: 38695485

Becker F, Ouzin M, Liedtke S, Raba K, Kogler G. DNA Damage Response After Treatment of Cycling and Quiescent Cord Blood Hematopoietic Stem Cells With Distinct Genotoxic Noxae. Stem Cells. 2024 Feb 8;42(2):158-171. doi: 10.1093/stmcls/sxad085. PMID: 37962865; PMCID: PMC10852021

Ouzin M, Wesselborg S, Fritz G, Kogler G. Evaluation of Genotoxic Effects of N-Methyl-N-Nitroso-Urea and Etoposide on the Differentiation Potential of MSCs from Umbilical Cord Blood and Bone Marrow. Cells. 2024 Dec 23;13(24):2134. doi: 10.3390/cells13242134. PMID: 39768222; PMCID: PMC11675027

Wynen F, Krautstrunk J, Müller LM, Graf V, Brinkmann V, Fritz G. Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans. Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119591. doi: 10.1016/j.bbamcr.2023.119591. Epub 2023 Sep 18. PMID: 37730131

Mann J, Niedermayer K, Krautstrunk J, Abbey L, Wiesmüller L, Piekorz RP, Fritz G. Combined inhibition of RAD51 and CHK1 causes synergistic toxicity in cisplatin resistant cancer cells by triggering replication fork collapse. Int J Cancer. 2024 Sep 6. doi: 10.1002/ijc.35164. Epub ahead of print. PMID: 39239809

Loerch C, Szepanowski LP, Reiss J, Adjaye J, Graffmann N. Forskolin induces FXR expression and enhances maturation of iPSC-derived hepatocyte-like cells. Front Cell Dev Biol. 2024 Apr 17;12:1383928. doi: 10.3389/fcell.2024.1383928. PMID: 38694820; PMCID: PMC11061433

Funk LM, Poschmann G, Rabe von Pappenheim F, Chari A, Stegmann KM, Dickmanns A, Wensien M, Eulig N, Paknia E, Heyne G, Penka E, Pearson AR, Berndt C, Fritz T, Bazzi S, Uranga J, Mata RA, Dobbelstein M, Hilgenfeld R, Curth U, Tittmann K. Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nat Commun. 2024 Jan 9;15(1):411. doi: 10.1038/s41467-023-44621-0. PMID: 38195625; PMCID: PMC10776599

Hamre K, Zhang W, Austgulen MH, Mykkeltvedt E, Yin P, Berntssen M, Espe M, Berndt C. Systemic and strict regulation of the glutathione redox state in mitochondria and cytosol is needed for zebrafish ontogeny. Biochim Biophys Acta Gen Subj. 2024 Jun;1868(6):130603. doi: 10.1016/j.bbagen.2024.130603. Epub 2024 Mar 21. PMID: 38521470

Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M. Ferroptosis in health and disease. Redox Biol. 2024 Sep;75:103211. doi: 10.1016/j.redox.2024.103211. Epub 2024 May 30. PMID: 38908072; PMCID: PMC11253697

Szepanowski LP, Wruck W, Kapr J, Rossi A, Fritsche E, Krutmann J, Adjaye J. Cockayne Syndrome Patient iPSC-Derived Brain Organoids and Neurospheres Show Early Transcriptional Dysregulation of Biological Processes Associated with Brain Development and Metabolism. Cells. 2024 Mar 28;13(7):591. doi: 10.3390/cells13070591. PMID: 38607030; PMCID: PMC11011893

Schmitt L, Hoppe J, Cea-Medina P, Bruch PM, Krings KS, Lechtenberg I, Drießen D, Peter C, Bhatia S, Dietrich S, Stork B, Fritz G, Gohlke H, Müller TJJ, Wesselborg S. Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs). Cell Death Discov. 2024 Jun 11;10(1):279. doi: 10.1038/s41420-024-02056-6. PMID: 38862521; PMCID: PMC11167047

Schmitt L, Lechtenberg I, Drießen D, Flores-Romero H, Skowron MA, Sekeres M, Hoppe J, Krings KS, Llewellyn TR, Peter C, Stork B, Qin N, Bhatia S, Nettersheim D, Fritz G, García-Sáez AJ, Müller TJJ, Wesselborg S. Novel meriolin derivatives activate the mitochondrial apoptosis pathway in the presence of antiapoptotic Bcl-2. Cell Death Discov. 2024 Mar 9;10(1):125. doi: 10.1038/s41420-024-01901-y. PMID: 38461295; PMCID: PMC10924942

Krings KS, Wassenberg TR, Cea-Medina P, Schmitt L, Lechtenberg I, Llewellyn TR, Qin N, Gohlke H, Wesselborg S, Müller TJJ. Novel 4-alkoxy Meriolin Congeners Potently Induce Apoptosis in Leukemia and Lymphoma Cells. Molecules. 2024 Dec 23;29(24):6050. doi: 10.3390/molecules29246050. PMID: 39770138; PMCID: PMC11676355

Ebbert L, von Montfort C, Wenzel CK, Reichert AS, Stahl W, Brenneisen P. A Combination of Cardamonin and Doxorubicin Selectively Affect Cell Viability of Melanoma Cells: An In Vitro Study. Antioxidants (Basel). 2024 Jul 19;13(7):864. doi: 10.3390/antiox13070864. PMID: 39061932; PMCID: PMC11274308

Kondadi AK, Reichert AS. Mitochondrial Dynamics at Different Levels: From Cristae Dynamics to Interorganellar Cross Talk. Annu Rev Biophys. 2024 Jul;53(1):147-168. doi: 10.1146/annurev-biophys-030822-020736. Epub 2024 Jun 28. PMID: 38166176

Keßel HE, Masjosthusmann S, Bartmann K, Blum J, Dönmez A, Förster N, Klose J, Mosig A, Pahl M, Leist M, Scholze M, Fritsche E. The impact of biostatistics on hazard characterization using in vitro developmental neurotoxicity assays. ALTEX. 2023;40(4):619-634. doi: 10.14573/altex.2210171. Epub 2023 Jun 27. PMID: 37422925

Blum J, Masjosthusmann S, Bartmann K, Bendt F, Dolde X, Dönmez A, Förster N, Holzer AK, Hübenthal U, Keßel HE, Kilic S, Klose J, Pahl M, Stürzl LC, Mangas I, Terron A, Crofton KM, Scholze M, Mosig A, Leist M, Fritsche E. Establishment of a human cell-based in vitro battery to assess developmental neurotoxicity hazard of chemicals. Chemosphere. 2023 Jan;311(Pt 2):137035. doi: 10.1016/j.chemosphere.2022.137035. Epub 2022 Oct 31. PMID: 36328314

Berning L, Lenz T, Bergmann AK, Poschmann G, Brass HUC, Schlütermann D, Friedrich A, Mendiburo MJ, David C, Akgün S, Pietruszka J, Stühler K, Stork B. The Golgi stacking protein GRASP55 is targeted by the natural compound prodigiosin. Cell Commun Signal. 2023 Oct 5;21(1):275. doi: 10.1186/s12964-023-01275-1. PMID: 37798768; PMCID: PMC10552397

Mboni-Johnston IM, Kouidrat NMZ, Hirsch C, Weber AG, Meißner A, Adjaye J, Schupp N. Sensitivity of Human Induced Pluripotent Stem Cells and Thereof Differentiated Kidney Proximal Tubular Cells towards Selected Nephrotoxins. Int J Mol Sci. 2023 Dec 20;25(1):81. doi: 10.3390/ijms25010081. PMID: 38203251; PMCID: PMC10779191

Ouzin M, Kogler G. Mesenchymal Stromal Cells: Heterogeneity and Therapeutical Applications. Cells. 2023 Aug 10;12(16):2039. doi: 10.3390/cells12162039. PMID: 37626848; PMCID: PMC10453316

Nguyen L, Thewes L, Westerhoff M, Wruck W, Reichert AS, Berndt C, Adjaye J. JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis. Cells. 2023 Sep 2;12(17):2197. doi: 10.3390/cells12172197. PMID: 37681928; PMCID: PMC10486975

Esser LM, Li Q, Jüdt M, Kähne T, Stork B, Grimmler M, Wesselborg S, Peter C. The Impact of p70S6 Kinase-Dependent Phosphorylation of Gemin2 in UsnRNP Biogenesis. Int J Mol Sci. 2023 Oct 25;24(21):15552. doi: 10.3390/ijms242115552. PMID: 37958537; PMCID: PMC10649565

Nguyen A, Lugarini F, David C, Hosnani P, Alagöz Ç, Friedrich A, Schlütermann D, Knotkova B, Patel A, Parfentev I, Urlaub H, Meinecke M, Stork B, Faesen AC. Metamorphic proteins at the basis of human autophagy initiation and lipid transfer. Mol Cell. 2023 Jun 15;83(12):2077-2090.e12. doi: 10.1016/j.molcel.2023.04.026. Epub 2023 May 19. PMID: 37209685

Esser LM, Schmitz K, Hillebrand F, Erkelenz S, Schaal H, Stork B, Grimmler M, Wesselborg S, Peter C. Phosphorylation of pICln by the autophagy activating kinase ULK1 regulates snRNP biogenesis and splice activity of the cell. Comput Struct Biotechnol J. 2023 Mar 16;21:2100-2109. doi: 10.1016/j.csbj.2023.03.015. PMID: 36968021; PMCID: PMC10034211

Nakhaei-Rad S, Haghighi F, Bazgir F, Dahlmann J, Busley AV, Buchholzer M, Kleemann K, Schänzer A, Borchardt A, Hahn A, Kötter S, Schanze D, Anand R, Funk F, Kronenbitter AV, Scheller J, Piekorz RP, Reichert AS, Volleth M, Wolf MJ, Cirstea IC, Gelb BD, Tartaglia M, Schmitt JP, Krüger M, Kutschka I, Cyganek L, Zenker M, Kensah G, Ahmadian MR. Molecular and cellular evidence for the impact of a hypertrophic cardiomyopathy-associated RAF1 variant on the structure and function of contractile machinery in bioartificial cardiac tissues. Commun Biol. 2023 Jun 21;6(1):657. doi: 10.1038/s42003-023-05013-8. PMID: 37344639; PMCID: PMC10284840.

Martins S, Erichsen L, Datsi A, Wruck W, Goering W, Chatzantonaki E, de Amorim VCM, Rossi A, Chrzanowska KH, Adjaye J. Impaired p53-Mediated DNA Damage Response Contributes to Microcephaly in Nijmegen Breakage Syndrome Patient-Derived Cerebral Organoids. Cells. 2022 Feb 25;11(5):802. doi: 10.3390/cells11050802. PMID: 35269426; PMCID: PMC8909307

Förster N, Butke J, Keßel HE, Bendt F, Pahl M, Li L, Fan X, Leung PC, Klose J, Masjosthusmann S, Fritsche E, Mosig A. Reliable identification and quantification of neural cells in microscopic images of neurospheres. Cytometry A. 2022 May;101(5):411-422. doi: 10.1002/cyto.a.24514. Epub 2021 Nov 19. PMID: 34747115

Koch K, Bartmann K, Hartmann J, Kapr J, Klose J, Kuchovská E, Pahl M, Schlüppmann K, Zühr E, Fritsche E. Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation. Front Toxicol. 2022 Mar 2;4:816370. doi: 10.3389/ftox.2022.816370. PMID: 35295221; PMCID: PMC8915868

Klose J, Pahl M, Bartmann K, Bendt F, Blum J, Dolde X, Förster N, Holzer AK, Hübenthal U, Keßel HE, Koch K, Masjosthusmann S, Schneider S, Stürzl LC, Woeste S, Rossi A, Covaci A, Behl M, Leist M, Tigges J, Fritsche E. Neurodevelopmental toxicity assessment of flame retardants using a human DNT in vitro testing battery. Cell Biol Toxicol. 2022 Oct;38(5):781-807. doi: 10.1007/s10565-021-09603-2. Epub 2021 May 10. PMID: 33969458; PMCID: PMC9525352

Klose J, Li L, Pahl M, Bendt F, Hübenthal U, Jüngst C, Petzsch P, Schauss A, Köhrer K, Leung PC, Wang CC, Koch K, Tigges J, Fan X, Fritsche E. Application of the adverse outcome pathway concept for investigating developmental neurotoxicity potential of Chinese herbal medicines by using human neural progenitor cells in vitro. Cell Biol Toxicol. 2023 Feb;39(1):319-343. doi: 10.1007/s10565-022-09730-4. Epub 2022 Jun 15. PMID: 35701726; PMCID: PMC10042984

Graffmann N, Scherer B, Adjaye J. In vitro differentiation of pluripotent stem cells into hepatocyte like cells - Basic principles and current progress. Stem Cell Res. 2022 May;61:102763. doi: 10.1016/j.scr.2022.102763. Epub 2022 Mar 24. PMID: 35395623

Wilms C, Lepka K, Häberlein F, Edwards S, Felsberg J, Pudelko L, Lindenberg TT, Poschmann G, Qin N, Volbracht K, Prozorovski T, Meuth SG, Kahlert UD, Remke M, Aktas O, Reifenberger G, Bräutigam L, Odermatt B, Berndt C. Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: Enzymatic Taoism. Redox Biol. 2022 Feb;49:102221. doi: 10.1016/j.redox.2021.102221. Epub 2021 Dec 21. PMID: 34952462; PMCID: PMC8715126

Erenburg IN, Hänsch S, Chacko FM, Hamacher A, Wintgens S, Stuhldreier F, Poschmann G, Spitz O, Stühler K, Wesselborg S, Hegemann JH, Smits SHJ, Weidtkamp-Peters S, Schmitt L. Heterologously secreted MbxA from Moraxella bovis induces a membrane blebbing response of the human host cell. Sci Rep. 2022 Oct 24;12(1):17825. doi: 10.1038/s41598-022-22480-x. PMID: 36280777; PMCID: PMC9592583

Stuhldreier F, Schmitt L, Lenz T, Hinxlage I, Zimmermann M, Wollnitzke P, Schliehe-Diecks J, Liu Y, Jäger P, Geyh S, Teusch N, Peter C, Bhatia S, Haas R, Levkau B, Reichert AS, Stühler K, Proksch P, Stork B, Wesselborg S. The mycotoxin viriditoxin induces leukemia- and lymphoma-specific apoptosis by targeting mitochondrial metabolism. Cell Death Dis. 2022 Nov 8;13(11):938. doi: 10.1038/s41419-022-05356-w. PMID: 36347842; PMCID: PMC9643474

Cox J, Esser LM, Jüdt M, Schmitz K, Reiffert K, Grimmler M, Stork B, Wesselborg S, Peter C. NF90/NFAR (nuclear factors associated with dsRNA) - a new methylation substrate of the PRMT5-WD45-RioK1 complex. Biol Chem. 2022 Aug 31;403(10):907-915. doi: 10.1515/hsz-2022-0136. PMID: 36040368

Kumar R, Reichert AS. Common Principles and Specific Mechanisms of Mitophagy from Yeast to Humans. Int J Mol Sci. 2021 Apr 22;22(9):4363. doi: 10.3390/ijms22094363. PMID: 33922020; PMCID: PMC8122514

Müntjes K, Devan SK, Reichert AS, Feldbrügge M. Linking transport and translation of mRNAs with endosomes and mitochondria. EMBO Rep. 2021 Oct 5;22(10):e52445. doi: 10.15252/embr.202152445. Epub 2021 Aug 17. PMID: 34402186; PMCID: PMC8490996

Ariantari NP, Frank M, Gao Y, Stuhldreier F, Kiffe-Delf AL, Hartmann R, Höfert SP, Janiak C, Wesselborg S, Müller WEG, Kalscheuer R, Liu Z, Proksch P: Fusaristatins D–F and (7S,8R)-(−)-chlamydospordiol from Fusarium sp. BZCB-CA, an endophyte of Bothriospermum chinense,Tetrahedron,Volume 85, 2021,132065, ISSN 0040-4020, https://doi.org/10.1016/j.tet.2021.132065

Schmitt L, Hinxlage I, Cea PA, Gohlke H, Wesselborg S. 40 Years of Research on Polybrominated Diphenyl Ethers (PBDEs)-A Historical Overview and Newest Data of a Promising Anticancer Drug. Molecules. 2021 Feb 13;26(4):995. doi: 10.3390/molecules26040995. PMID: 33668501; PMCID: PMC7918430

Schürmann L, Schumacher L, Roquette K, Brozovic A, Fritz G. Inhibition of the DSB repair protein RAD51 potentiates the cytotoxic efficacy of doxorubicin via promoting apoptosis-related death pathways. Cancer Lett. 2021 Nov 1;520:361-373. doi: 10.1016/j.canlet.2021.08.006. Epub 2021 Aug 11. PMID: 34389435

Georgy J, Arlt Y, Moll JM, Ouzin M, Weitz HT, Gremer L, Willbold D, Grötzinger J, Thives-Kurenbach F, Scheller J, Floss DM. Tryptophan (W) at position 37 of murine IL-12/IL-23 p40 is mandatory for binding to IL-12Rβ1 and subsequent signal transduction. J Biol Chem. 2021 Nov;297(5):101295. doi: 10.1016/j.jbc.2021.101295. Epub 2021 Oct 9. PMID: 34637790; PMCID: PMC8571081

Sun Y, Berleth N, Wu W, Schlütermann D, Deitersen J, Stuhldreier F, Berning L, Friedrich A, Akgün S, Mendiburo MJ, Wesselborg S, Conrad M, Berndt C, Stork B.Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells. Cell Death Dis. 2021 Oct 29;12(11):1028. doi: 10.1038/s41419-021-04306-2. PMID: 34716292; PMCID: PMC8556316

Prozorovski T, Kroll C, Berndt C, Aktas O. At the interface between metabolism and redox regulation: Sirtuin 1 as checkpoint for neurogenesis and longevity. In „Redox regulation of differentiation and de-differention, CRC press 2021, doi.org/10.1201/9781003204091