Publikationen

Funk LM, Poschmann G, Rabe von Pappenheim F, Chari A, Stegmann KM, Dickmanns A, Wensien M, Eulig N, Paknia E, Heyne G, Penka E, Pearson AR, Berndt C, Fritz T, Bazzi S, Uranga J, Mata RA, Dobbelstein M, Hilgenfeld R, Curth U, Tittmann K.  Multiple redox switches of the SARS-CoV-2 main protease in vitro provide opportunities for drug design. Nat Commun 15: 411 (2024),  doi: 10.1038/s41467-023-44621-0

Hamre K, Zhang W, Austgulen MH, Mykkeltvedt E, Yin P, Berntssen M, Espe M, Berndt C.; Systemic and strict regulation of the glutathione redox state in mitochondria and cytosol is needed for zebrafish ontogeny Biochim Biophys Acta Gen Subj 1868: 130603 (2024), doi: 10.1016/j.bbagen.2024.130603

Berndt C, Alborzinia H, Amen VS, Ayton S, Barayeu U, Bartelt A, Bayir H, Bebber CM, Birsoy K, Böttcher JP, Brabletz S, Brabletz T, Brown AR, Brüne B, Bulli G, Bruneau A, Chen Q, DeNicola GM, Dick TP, Distéfano A, Dixon SJ, Engler JB, Esser-von Bieren J, Fedorova M, Friedmann Angeli JP, Friese MA, Fuhrmann DC, García-Sáez AJ, Garbowicz K, Götz M, Gu W, Hammerich L, Hassannia B, Jiang X, Jeridi A, Kang YP, Kagan VE, Konrad DB, Kotschi S, Lei P, Le Tertre M, Lev S, Liang D, Linkermann A, Lohr C, Lorenz S, Luedde T, Methner A, Michalke B, Milton AV, Min J, Mishima E, Müller S, Motohashi H, Muckenthaler MU, Murakami S, Olzmann JA, Pagnussat G, Pan Z, Papagiannakopoulos T, Pedrera Puentes L, Pratt DA, Proneth B, Ramsauer L, Rodriguez R, Saito Y, Schmidt F, Schmitt C, Schulze A, Schwab A, Schwantes A, Soula M, Spitzlberger B, Stockwell BR, Thewes L, Thorn-Seshold O, Toyokuni S, Tonnus W, Trumpp A, Vandenabeele P, Vanden Berghe T, Venkataramani V, Vogel FCE, von Karstedt S, Wang F, Westermann F, Wientjens C, Wilhelm C, Wölk M, Wu K, Yang X, Yu F, Zou Y, Conrad M.; Ferroptosis in health and disease.  Redox Biol 75: 103211 (2024), doi: 10.1016/j.redox.2024.103211

Schmitt L, Hoppe J, Cea-Medina P, Bruch PM, Krings KS, Lechtenberg I, Drießen D, Peter C, Bhatia S, Dietrich S, Stork B, Fritz G, Gohlke H, Müller TJJ, Wesselborg S. Novel meriolin derivatives potently inhibit cell cycle progression and transcription in leukemia and lymphoma cells via inhibition of cyclin-dependent kinases (CDKs). Cell Death Discov. 2024 Jun 11;10(1):279. doi: 10.1038/s41420-024-02056-6. PMID: 38862521; PMCID: PMC11167047.

Szepanowski LP, Wruck W, Kapr J, Rossi A, Fritsche E, Krutmann J, Adjaye J. Cockayne Syndrome Patient iPSC-Derived Brain Organoids and Neurospheres Show Early Transcriptional Dysregulation of Biological Processes Associated with Brain Development and Metabolism. Cells. 2024 Mar 28;13(7):591. doi: 10.3390/cells13070591. PMID: 38607030; PMCID: PMC11011893.

Loerch C, Szepanowski LP, Reiss J, Adjaye J, Graffmann N. Forskolin induces FXR expression and enhances maturation of iPSC-derived hepatocyte-like cells. Front Cell Dev Biol. 2024 Apr 17;12:1383928. doi: 10.3389/fcell.2024.1383928. PMID: 38694820; PMCID: PMC11061433.

Mboni-Johnston IM, Kouidrat NMZ, Hirsch C, Weber AG, Meißner A, Adjaye J, Schupp N. Sensitivity of Human Induced Pluripotent Stem Cells and Thereof Differentiated Kidney Proximal Tubular Cells towards Selected Nephrotoxins. Int J Mol Sci. 2023 Dec 20;25(1):81. doi: 10.3390/ijms25010081. PMID: 38203251; PMCID: PMC10779191.

Wynen F, Krautstrunk J, Müller LM, Graf V, Brinkmann V, Fritz G. Cisplatin-induced DNA crosslinks trigger neurotoxicity in C. elegans. Biochim Biophys Acta Mol Cell Res. 2024 Jan;1871(1):119591. doi: 10.1016/j.bbamcr.2023.119591. Epub 2023 Sep 18. PMID: 37730131.

Becker F, Ouzin M, Liedtke S, Raba K, Kogler G. DNA damage response after treatment of cycling and quiescent cord blood hematopoietic stem cells with distinct genotoxic noxae. Stem Cells. 2023 Nov 14:sxad085. doi: 10.1093/stmcls/sxad085. Epub ahead of print. PMID: 3796286

Nguyen L, Thewes L, Westerhoff M, Wruck W, Reichert AS, Berndt C, Adjaye J. JNK Signalling Regulates Self-Renewal of Proliferative Urine-Derived Renal Progenitor Cells via Inhibition of Ferroptosis. Cells. 2023 Sep 2;12(17):2197. doi: 10.3390/cells12172197. PMID: 37681928; PMCID: PMC10486975.

Stuhldreier, F., Schmitt, L., Lenz,T., Hinxlage, I., Zimmermann, M., Wollnitzke, P., Schliehe-Diecks, J., Liu, Y., Jäger, P., Geyh, S., Teusch, N., Peter, C., Bhatia, S., Haas, R., Levkau, B., Reichert, A.S., Stühler, K., Proksch, P., Stork, B. and Wesselborg, S.: The mycotoxin viriditoxin induces leukemia- and lymphomaspecific apoptosis by targeting mitochondrial metabolism (2022), Cell Death and Disease 13:938.

Wilms, C., Lepka, K., Häberlein, F., Edwards, S., Felsberg, J., Pudelko, L., Lindenberg, T.T., Poschmann, G., Qing, N., Volbracht, K., Prozorovski, T., Meuth, S.G., Kahlerth, U.D.,  Remke, M., Aktas, O., Reifenberger, G., Bräutigam, L, Odermatt, B., and  Berndt, C.: Glutaredoxin 2 promotes SP-1-dependent CSPG4 transcription and migration of wound healing NG2 glia and glioma cells: enzymatic Taoism (2022),  Redox Biol. 49: 102221.

Katharina Koch, Kristina Bartmann, Julia Hartmann, Julia Kapr, Jördis Klose, Eliška Kuchovská, Melanie Pahl, Kevin Schlüppmann, Etta Zühr, Ellen Fritsche: 'Scientific validation of human Neurosphere Assays for developmental neurotoxicity evaluation (2022)', Frontiers in Toxicology, section Neurotoxicology (Manuscript ID: 816370)

Sun, Y., Berleth, N., Wu, W., Schlütermann, D., Deitersen, D., Stuhldreier, F., Berning, L., Friedrich, A., Akguen, S., Mendiburo, M., Wesselborg, S., Conrad, M., Berndt, C., and Stork, B. : Fin56-induced ferroptosis is supported by autophagy-mediated GPX4 degradation and functions synergistically with mTOR inhibition to kill bladder cancer cells (2021), Cell Death Dis. 12: 1028.

Müntjes, K., Devan, SK., Reichert, AS., & Feldbrügge M.: Linking transport and translation of mRNAs with endosomes and mitochondria (2021), EMBO reports 22: e52445.

Kumar, R. & Reichert RS.: Common Principles and Specific Mechanisms of Mitophagy from Yeast to Humans (2021), Int. J. Mol. Sci. 22, 4363.