Research projects

Project 1a - Comparative analyses of DNA damage response pathways in hepatocytes and neurons differentiated from healthy and NBS-patient derived iPSCs

Project 1b - Hypoxia and Sirtuin 1, two factors linking DNA damage and differentiation in neural stem/ progenitor cells

Project 1c -Investigations on DNA repair capacities of human neural progenitor cells (NPC) depending on the degree of differentiation and cell type

Project 1d - Molecular mechanisms regulating the differentiation potential of neural stem and progenitor cells upon gamma irradiation

Project 1e - Impact of genotoxins on autophagic processes during neuronal differentiation

Project 2a - Effect of DNA damage caused by nephrotoxins and oxidative stress on differentiation and dedifferentiation processes in kidney cells

Project 3a - Impact of hemato-oncological therapies on genomic stability and differentiation capacity of human bone marrow-derived mesenchymal stromal cells in the context of therapy-related hematopoietic insufficiency and development of secondary myeloid

Project 3b - Sublethal Genomic Damage of Naïve B cells - Consequences for Differentiation and Function with a Focus on Development of Autoimmunity

Project 4 - Influence of nitrosamines and ionizing radiation on the chondrogenic differentiation potential of neonatal and adult stromal cells

Project 5a - Impact of genotoxins on cardiovascular differentiation of murine and human stem- and progenitor cells: Relevance of mechanisms of DNA repair and DNA damage response (DDR)

Project 5b - Role of metabolism and mitochondrial function for stem cell differentiation and stress responses upon genotoxic noxae

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