Research projects

Project 1a - Comparative analysis of the effect of cisplatin on neurogenesis and nephrogenesis in organoid models based on iPSCs from Cockayne syndrome patients and healthy donors

Project 1b - Effect of nuclearly formed H2O2 on genomic stability and differentiation of neural stem/progenitor cells

Project 1c - Developmental stage-specific effects of genotoxins on the differentiation of neural progenitor cells into glial cells and their influence on the functionality of neural networks

Project 1d - Influence of genotoxins on nucleophagic, chaperone-mediated and unconventional autophagic processes during neuronal differentiation

Project 2a - Clarification of the damaging effects of genotoxic and non-genotoxic nephrotoxins on tubule cell regeneration

Project 3a - The effect of genotoxicity on the immune microenvironment and resulting or immunotherapeutic chemotherapeutic pretreated cancer patients

Project 3b - Effects of therapeutic and environmental noxious agents on the differentiation and activation of pro-inflammatory fibroblast subsets and their interaction with immune cells

Project 3c - Influence of genotoxins on nominal and preleukaemic altered neonatal CD34+ haematopoietic stem cells and B-cell differentiation

Project 4a - Toxic effects of reactive oxygen species on the health of adult muscle stem cells

Project 4b - Pharmacological and genetic inhibition of selected mechanisms of DNA repair: influence on cardiovascular differentiation processes of hiPSC in vitro and developmental processes in vivo (C. elegans)

Project 4c - Role of mitochondrial quality control for the adaptation of stem cells and differentiated cells to sublethal doses of genotoxic noxious agents

Responsible for the content: Koordination GRK2578